U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Severe depression

MedGen UID:
669675
•Concept ID:
C0588008
•
Mental or Behavioral Dysfunction
SNOMED CT: Severe depression (310497006)

Professional guidelines

PubMed

Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial.
Raison CL, Sanacora G, Woolley J, Heinzerling K, Dunlop BW, Brown RT, Kakar R, Hassman M, Trivedi RP, Robison R, Gukasyan N, Nayak SM, Hu X, O'Donnell KC, Kelmendi B, Sloshower J, Penn AD, Bradley E, Kelly DF, Mletzko T, Nicholas CR, Hutson PR, Tarpley G, Utzinger M, Lenoch K, Warchol K, Gapasin T, Davis MC, Nelson-Douthit C, Wilson S, Brown C, Linton W, Ross S, Griffiths RR
JAMA 2023 Sep 5;330(9):843-853. doi: 10.1001/jama.2023.14530. PMID: 37651119Free PMC Article
Updates in treatment of depression in children and adolescents.
Hazell P
Curr Opin Psychiatry 2021 Nov 1;34(6):593-599. doi: 10.1097/YCO.0000000000000749. PMID: 34456305
Comorbid Anxiety and Depression: Clinical and Conceptual Consideration and Transdiagnostic Treatment.
Choi KW, Kim YK, Jeon HJ
Adv Exp Med Biol 2020;1191:219-235. doi: 10.1007/978-981-32-9705-0_14. PMID: 32002932

Recent clinical studies

Etiology

App-Based Interventions for Moderate to Severe Depression: A Systematic Review and Meta-Analysis.
Bae H, Shin H, Ji HG, Kwon JS, Kim H, Hur JW
JAMA Netw Open 2023 Nov 1;6(11):e2344120. doi: 10.1001/jamanetworkopen.2023.44120. PMID: 37983028Free PMC Article
Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials.
Recchia F, Leung CK, Chin EC, Fong DY, Montero D, Cheng CP, Yau SY, Siu PM
Br J Sports Med 2022 Dec;56(23):1375-1380. Epub 2022 Sep 16 doi: 10.1136/bjsports-2022-105964. PMID: 36113975Free PMC Article
Depression in Children and Adolescents: Evaluation and Treatment.
Selph SS, McDonagh MS
Am Fam Physician 2019 Nov 15;100(10):609-617. PMID: 31730312
Severity classification on the Hamilton Depression Rating Scale.
Zimmerman M, Martinez JH, Young D, Chelminski I, Dalrymple K
J Affect Disord 2013 Sep 5;150(2):384-8. Epub 2013 Jun 4 doi: 10.1016/j.jad.2013.04.028. PMID: 23759278
Cognitive therapy vs medications in the treatment of moderate to severe depression.
DeRubeis RJ, Hollon SD, Amsterdam JD, Shelton RC, Young PR, Salomon RM, O'Reardon JP, Lovett ML, Gladis MM, Brown LL, Gallop R
Arch Gen Psychiatry 2005 Apr;62(4):409-16. doi: 10.1001/archpsyc.62.4.409. PMID: 15809408

Diagnosis

Updates in treatment of depression in children and adolescents.
Hazell P
Curr Opin Psychiatry 2021 Nov 1;34(6):593-599. doi: 10.1097/YCO.0000000000000749. PMID: 34456305
Depression in Children and Adolescents: Evaluation and Treatment.
Selph SS, McDonagh MS
Am Fam Physician 2019 Nov 15;100(10):609-617. PMID: 31730312
Severity classification on the Hamilton Depression Rating Scale.
Zimmerman M, Martinez JH, Young D, Chelminski I, Dalrymple K
J Affect Disord 2013 Sep 5;150(2):384-8. Epub 2013 Jun 4 doi: 10.1016/j.jad.2013.04.028. PMID: 23759278
Antidepressant drug effects and depression severity: a patient-level meta-analysis.
Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J
JAMA 2010 Jan 6;303(1):47-53. doi: 10.1001/jama.2009.1943. PMID: 20051569Free PMC Article
A scaled version of the General Health Questionnaire.
Goldberg DP, Hillier VF
Psychol Med 1979 Feb;9(1):139-45. doi: 10.1017/s0033291700021644. PMID: 424481

Therapy

Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials.
Recchia F, Leung CK, Chin EC, Fong DY, Montero D, Cheng CP, Yau SY, Siu PM
Br J Sports Med 2022 Dec;56(23):1375-1380. Epub 2022 Sep 16 doi: 10.1136/bjsports-2022-105964. PMID: 36113975Free PMC Article
Gut feelings: A randomised, triple-blind, placebo-controlled trial of probiotics for depressive symptoms.
Chahwan B, Kwan S, Isik A, van Hemert S, Burke C, Roberts L
J Affect Disord 2019 Jun 15;253:317-326. Epub 2019 May 9 doi: 10.1016/j.jad.2019.04.097. PMID: 31078831
A randomised controlled trial of dietary improvement for adults with major depression (the 'SMILES' trial).
Jacka FN, O'Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, Castle D, Dash S, Mihalopoulos C, Chatterton ML, Brazionis L, Dean OM, Hodge AM, Berk M
BMC Med 2017 Jan 30;15(1):23. doi: 10.1186/s12916-017-0791-y. PMID: 28137247Free PMC Article
Non-pharmacological treatment of depression: a systematic review and evidence map.
Farah WH, Alsawas M, Mainou M, Alahdab F, Farah MH, Ahmed AT, Mohamed EA, Almasri J, Gionfriddo MR, Castaneda-Guarderas A, Mohammed K, Wang Z, Asi N, Sawchuk CN, Williams MD, Prokop LJ, Murad MH, LeBlanc A
Evid Based Med 2016 Dec;21(6):214-221. Epub 2016 Nov 11 doi: 10.1136/ebmed-2016-110522. PMID: 27836921
Antidepressant drug effects and depression severity: a patient-level meta-analysis.
Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J
JAMA 2010 Jan 6;303(1):47-53. doi: 10.1001/jama.2009.1943. PMID: 20051569Free PMC Article

Prognosis

Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany.
Ziegler AG, Kick K, Bonifacio E, Haupt F, Hippich M, Dunstheimer D, Lang M, Laub O, Warncke K, Lange K, Assfalg R, Jolink M, Winkler C, Achenbach P; Fr1da Study Group
JAMA 2020 Jan 28;323(4):339-351. doi: 10.1001/jama.2019.21565. PMID: 31990315Free PMC Article
Posttraumatic stress, anxiety and depression following miscarriage and ectopic pregnancy: a multicenter, prospective, cohort study.
Farren J, Jalmbrant M, Falconieri N, Mitchell-Jones N, Bobdiwala S, Al-Memar M, Tapp S, Van Calster B, Wynants L, Timmerman D, Bourne T
Am J Obstet Gynecol 2020 Apr;222(4):367.e1-367.e22. Epub 2019 Dec 13 doi: 10.1016/j.ajog.2019.10.102. PMID: 31953115
Depression and anxiety in long-term survivors 5 and 10 years after cancer diagnosis.
Götze H, Friedrich M, Taubenheim S, Dietz A, Lordick F, Mehnert A
Support Care Cancer 2020 Jan;28(1):211-220. Epub 2019 Apr 18 doi: 10.1007/s00520-019-04805-1. PMID: 31001695
Epidemiology of suicide: recent developments.
Baldessarini RJ
Epidemiol Psychiatr Sci 2019 Nov 7;29:e71. doi: 10.1017/S2045796019000672. PMID: 31696818Free PMC Article
Postpsychotic depression in schizophrenia.
McGlashan TH, Carpenter WT Jr
Arch Gen Psychiatry 1976 Feb;33(2):231-9. doi: 10.1001/archpsyc.1976.01770020065011. PMID: 766720

Clinical prediction guides

Efficacy and Safety of Auricular Acupuncture for Depression: A Randomized Clinical Trial.
de Oliveira Rodrigues DM, Menezes PR, Machado Ribeiro Silotto AE, Heps A, Pereira Sanches NM, Schveitzer MC, Faisal-Cury A
JAMA Netw Open 2023 Nov 1;6(11):e2345138. doi: 10.1001/jamanetworkopen.2023.45138. PMID: 38032640Free PMC Article
The effect of a Mediterranean diet on the symptoms of depression in young males (the "AMMEND: A Mediterranean Diet in MEN with Depression" study): a randomized controlled trial.
Bayes J, Schloss J, Sibbritt D
Am J Clin Nutr 2022 Aug 4;116(2):572-580. doi: 10.1093/ajcn/nqac106. PMID: 35441666
Severity classification on the Hamilton Depression Rating Scale.
Zimmerman M, Martinez JH, Young D, Chelminski I, Dalrymple K
J Affect Disord 2013 Sep 5;150(2):384-8. Epub 2013 Jun 4 doi: 10.1016/j.jad.2013.04.028. PMID: 23759278
Antidepressant drug effects and depression severity: a patient-level meta-analysis.
Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J
JAMA 2010 Jan 6;303(1):47-53. doi: 10.1001/jama.2009.1943. PMID: 20051569Free PMC Article
The PHQ-9: validity of a brief depression severity measure.
Kroenke K, Spitzer RL, Williams JB
J Gen Intern Med 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x. PMID: 11556941Free PMC Article

Recent systematic reviews

Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials.
Recchia F, Leung CK, Chin EC, Fong DY, Montero D, Cheng CP, Yau SY, Siu PM
Br J Sports Med 2022 Dec;56(23):1375-1380. Epub 2022 Sep 16 doi: 10.1136/bjsports-2022-105964. PMID: 36113975Free PMC Article
Internet-Based Cognitive Behavioral Therapy for Depression: A Systematic Review and Individual Patient Data Network Meta-analysis.
Karyotaki E, Efthimiou O, Miguel C, Bermpohl FMG, Furukawa TA, Cuijpers P; Individual Patient Data Meta-Analyses for Depression (IPDMA-DE) Collaboration, Riper H, Patel V, Mira A, Gemmil AW, Yeung AS, Lange A, Williams AD, Mackinnon A, Geraedts A, van Straten A, Meyer B, Björkelund C, Knaevelsrud C, Beevers CG, Botella C, Strunk DR, Mohr DC, Ebert DD, Kessler D, Richards D, Littlewood E, Forsell E, Feng F, Wang F, Andersson G, Hadjistavropoulos H, Christensen H, Ezawa ID, Choi I, Rosso IM, Klein JP, Shumake J, Garcia-Campayo J, Milgrom J, Smith J, Montero-Marin J, Newby JM, Bretón-López J, Schneider J, Vernmark K, Bücker L, Sheeber LB, Warmerdam L, Farrer L, Heinrich M, Huibers MJH, Kivi M, Kraepelien M, Forand NR, Pugh N, Lindefors N, Lintvedt O, Zagorscak P, Carlbring P, Phillips R, Johansson R, Kessler RC, Brabyn S, Perini S, Rauch SL, Gilbody S, Moritz S, Berger T, Pop V, Kaldo V, Spek V, Forsell Y
JAMA Psychiatry 2021 Apr 1;78(4):361-371. doi: 10.1001/jamapsychiatry.2020.4364. PMID: 33471111Free PMC Article
New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis.
Charlson F, van Ommeren M, Flaxman A, Cornett J, Whiteford H, Saxena S
Lancet 2019 Jul 20;394(10194):240-248. Epub 2019 Jun 12 doi: 10.1016/S0140-6736(19)30934-1. PMID: 31200992Free PMC Article
Non-pharmacological treatment of depression: a systematic review and evidence map.
Farah WH, Alsawas M, Mainou M, Alahdab F, Farah MH, Ahmed AT, Mohamed EA, Almasri J, Gionfriddo MR, Castaneda-Guarderas A, Mohammed K, Wang Z, Asi N, Sawchuk CN, Williams MD, Prokop LJ, Murad MH, LeBlanc A
Evid Based Med 2016 Dec;21(6):214-221. Epub 2016 Nov 11 doi: 10.1136/ebmed-2016-110522. PMID: 27836921
A systematic review of St. John's wort for major depressive disorder.
Apaydin EA, Maher AR, Shanman R, Booth MS, Miles JN, Sorbero ME, Hempel S
Syst Rev 2016 Sep 2;5(1):148. doi: 10.1186/s13643-016-0325-2. PMID: 27589952Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...